Knockdown of MicroRNA-155 in Kupffer Cells Results in Immunosuppressive Effects and Prolongs Survival of Mouse Liver Allografts

Abstract

These data suggest miR-155 regulates the balance of Th1/Th2 cytokines and the maturation and function of KCs in mice. miR-155 repression in KCs positively regulates KC function toward immunosuppression and prolongs liver allograft survival.