A Facilitation Action of Reserpine on the Central Nervous System

Abstract

1. Data are presented to show a facilitation action of reserpine on the central nervous system. The drug hastens the onset of maximal tonic extensor seizures in mice receiving intravenous Metrazol or caffeine (but not strychnine). It lowers the convulsive seizure threshold of mice to electrical stimuli and antagonizes the anticonvulsant action of Dilantin. 2. Some possible mechanisms of action and certain clinical implications of this property of reserpine are suggested.