Synthesis, Characterization, and Imaging Performance of a New Class of Macrocyclic Hepatobiliary MR Contrast Agents

Abstract

Gd-2,5-BPA-DO3A provides dramatic and sustained SI enhancement of hepatic tissue in cats, rabbits, and Rhesus monkeys that was superior in all respects to the extracellular space MRI agent, Gd-HP-DO3A, that was employed as a control.