Formal Synthesis of (−)‐Cephalotaxine Based on a Tandem Hydroamination/Semipinacol Rearrangement Reaction

Abstract

Catalytic asymmetric formal synthesis of (−)-cephalotaxine has been accomplished based on an efficient tandem intramolecular hydroamination/asymmetric semipinacol rearrangement reaction catalyzed by chiral silver phosphate. During the course of the study it was observed that an advanced intermediate could be obtained in enantiopure form by enantiomer separation on silica gel. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.