The American Journal of Surgical Pathology · 1991 · 109 citations · 0 references
MedicineCell BiologyOncologyCancer GeneticsGene ExpressionNeoplasiaMuscle DevelopmentMuscle DifferentiationMuscle PathologyMuscle TissueSoft Tissue SarcomasMyogenic Lineage SpecificationSkeletal Muscle DifferentiationSkeletal Muscle HistologySkeletal Muscle TumorsSoft Tissue Sarcoma Histopathology
A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definitive evidence in support of the skeletal muscle nature of this enigmatic neoplasm.