Organic Letters · 2015 · 27 citations · 42 references
Natural SciencesChemistryMedicinal ChemistryInorganic ChemistryOrganic ChemistryOrganometallic ChemistryAddition ReactionsCoordination ChemistryHeterocycle SynthesisOrganic SynthesisOrganometallic Synthesis
A simple and efficient methodology is presented for the synthesis of a wide range of substituted imines. It is based on stabilizing readily available, but thermally labile, N-alkylnitrilium triflates with pyridine or DMAP to moderately air-stable adducts. These base-stabilized imine synthons react conveniently with phosphorus- and nitrogen-based nucleophiles to amidines and phosphaamidines.
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