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A Method for the Superfusion of Rat Hypothalami: Secretion of Luteinizing Hormone-Releasing Hormone (LH-RH)
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1977
Year
Adrenal GlandPituitary GlandNeuroendocrine MechanismHy-pothalamic TissueHypothalamic PeptideClinical ChemistryPublic HealthRat HypothalamiAnimal PhysiologyGrowth HormoneEndocrine MechanismHypothalamusNeuropharmacologySuperfusion SystemNervous SystemEndocrinologyPharmacologyHormone-releasing HormonePhysiologySecretion RateReceptor BiologyMedicine
A superfusion system for hy-pothalamic tissue is reported and the secretion rate of LH-RH is analyzed under different experimental conditions. The responsiveness of the preparation to stimuli like high K+, low Ca2+, and prostaglandin E2 was assessed. The usefulness of this preparation as an in vitro system to study the secretion rate of hypothalamic hormones is discussed.