Changes of resting-state EEG and functional connectivity in the sensor and source space of patients with major depression

Abstract

Dyfunctions of prefrontal neuronal circuits contribute to the pathophysiology of depression. Previous studies showed increased functional MRI (Greicius et al. 2007) and EEG connectivity in patients with depression (Fingelkurts et al. 2007; Leuchter et al. 2012). In this study we investigated a large sample of patients with major depression (n = 228) and gender- and age-matched healthy subjects (n = 215) using resting state EEG and eLORETA in terms of spectrotemporal dynamics and brain connectivity.