Multifunctional Fe<sub>3</sub>O<sub>4</sub>/TaO<sub><i>x</i></sub>Core/Shell Nanoparticles for Simultaneous Magnetic Resonance Imaging and X-ray Computed Tomography - Concepedia

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Multifunctional Fe<sub>3</sub>O<sub>4</sub>/TaO<sub><i>x</i></sub>Core/Shell Nanoparticles for Simultaneous Magnetic Resonance Imaging and X-ray Computed Tomography

233

Citations

32

References

2012

Year

Nohyun Lee, Hye Rim Cho, Myoung Hwan Oh, Soo Hong Lee, Kang Min Kim, Byung Hyo Kim, Kwangsoo Shin, Tae–Young Ahn, Jin Woo Choi, Yong‐Woon Kim,

Journal of the American Chemical Society

NanoparticlesMagnetic PropertiesEngineeringMetal NanoparticlesMagnetic ResonanceSol-gel ReactionBiomedical EngineeringChemistryMagnetic MaterialsMagnetic Resonance ImagingX-ray ImagingMagnetismNanomedicineX-ray Computed TomographyHealth SciencesMaterials ScienceMedical ImagingNanotechnologyContrast AgentMagnetic MaterialNanomaterialsMultimodal ImagingFunctional X-ray ImagingNano-drug DeliveryFunctional MaterialsTomography

Abstract

Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol-gel reaction of tantalum(V) ethoxide in a microemulsion containing Fe(3)O(4) nanoparticles (NPs) was used to synthesize multifunctional Fe(3)O(4)/TaO(x) core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor.

References

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