Enzymatic Evidence for Intrinsic Oxytocic Activity of the Pressor-Antidiuretic Hormone

Abstract

1. It has been shown that trypsin had no effect on the activity of oxytocin but destroyed both the pressor and oxytocic activities of arginine- vasopressin. These conclusions offer enzymatic evidence, in addition to the evidence already obtained from analytical and electrophoretic studies, for the inherent oxytocic activity of arginine-vasopressin. 2. It has also been demonstrated that a lysine-vasopressin preparation possessed oxytocic activity and that this activity was destroyed with the pressor activity by trypsin.