JNCI Journal of the National Cancer Institute · 1986 · 49 citations · 0 references
Life SciencesImmunologyInfectious DiseasesImmunology Of Infectious DiseasesMolecular VirologyVirologyAnimal VirusesOncogenic VirusesViral GeneticsViral InfectionsViral PathologyViral ReplicationAcquired Immunodeficiency SyndromeAnimal Viral PathogenesisImmunosuppressive FunctionPathogenicity AssaysPathogenicity MechanismsProviral Integration
The Mason-Pfizer monkey virus (MPMV) was reisolated from a cryopreserved sample of the original MPMV-containing rhesus breast carcinoma, and complete integrated MPMV provirus was detected in chromosomal DNA of this tumor. Reanalysis of the in vivo pathogenicity and molecular character of MPMV reisolated from the rhesus breast tumor and analysis of the original MPMV after long-term in vitro propagation in human and rhesus cells show that the original MPMV produces an acquired immunodeficiency similar to that caused by the recently described simian acquired immune deficiency syndrome type D retroviruses, and the MPMV genome and its immunosuppressive effect in vivo have remained stable despite prolonged in vitro passage in human and rhesus cells.