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The Potentiating Effect of ACTH and of Cortisone on Pressor Response to Intravenous Infusion of L-Nor-Epinephrine.
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1951
Year
Intravenous InfusionHypertensionAnesthesiaAdrenal GlandBlood Pressure ResponseSodium HomeostasisPotentiating EffectMedicinePhysiologyNeuroendocrine MechanismNeuropharmacologyPressor ResponseGlucocorticoidEndocrinologyPharmacologyAnesthesiologyEndocrine Hypertension
Summary1. The pressor response to an intravenous infusion of 2.1-13.9 μg per minute of 1-nor-epinephrine was studied, using a constant rate infusion apparatus, in 3 patients before and during the administration of ACTH and cortisone. 2. Striking potentiation of the blood pressure response to nor-epinephrine was noted within 24 hours after administration of 90-180 mg ACTH daily or 150-200 mg cortisone daily. The potentiating effect disappeared within 36 hours after the omission of these agents.