Planta Medica · 2014 · 25 citations · 0 references
Life SciencesBotanyPlant SciencesInflammationPlant BiochemistryStructure-activity RelationshipsAnti-inflammatory PharmacologyInflammation PharmacologyMedicinal Plant KnowledgeMedicinal PlantsStructure-activity Relationship AnalysisTerpenoid BiosynthesisAnti-inflammatory ActivityLeukotriene ProductionLeukotriene Synthesis InhibitorsNitric OxideNitric Oxide ProductionNitric Oxide ScavengingTerpene CompoundsTerpenoid Glycosides
Five new terpenes (<b>1</b>–<b>5</b>) and ten known compounds (<b>6</b>–<b>15</b>) were isolated from <i>Inula japonica</i>, and their structures were identified by spectroscopic analysis. Compounds <b>3</b> and <b>14</b> showed positive inhibitory effects on nitric oxide production. Furthermore, compound <b>14</b> suppressed both leukotriene C<sub>4</sub> synthesis and degranulation in <i>c-kit</i> ligand-induced bone marrow-derived mast cells.