Validation of Genetically Matched Wild-Type Strain and Lysyl Oxidase–Like 1 Knockout Mouse Model of Pelvic Organ Prolapse

Abstract

Genetically matched Loxl1 and Loxl1 strains can be reliably created by a backcross method and differentiate in their prolapse phenotype. Loxl1 mice demonstrate pathology primarily characterized by enlargement of the vagina. Further studies are needed to elucidate the cause of this finding.