Retinal Neurodegeneration in Type II Diabetic Otsuka Long-Evans Tokushima Fatty Rats

Abstract

OLETF exhibited a significantly reduced TRT, especially RNFL thickness, based on SD-OCT. Further, histology revealed increased apoptosis and a decrease in the number of ganglion cells. These results suggest that retinal neurodegeneration occurs in type II diabetic OLETF.