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PROBLEMS IN CHEMICAL MUTAGENESIS
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1951
Year
BiologyMustard GasChemical SafetyDr. MullerNatural SciencesGeneticsEvolutionary BiologyMolecular BiologyGenetic MechanismToxicologyGenetic VariationEcotoxicologyMolecular GeneticsGene EvolutionExperimental ToxicologyClear Positive ResultsMedicineMutagenesis
It is just ten years ago that Dr. Muller (1941), at the last Cold Spring Harbor Symposium on the gene and mutation, said that attempts to induce mutations by chemical means had not yet given any clear positive results. As a matter of fact, this statement was then no longer true. Clear positive results had been obtained only a few weeks earlier with mustard gas (Auerbach and Robson, 1942), but owing to a security ban on publication they had to be kept secret until some time after the war (Auerbach and Robson, 1946, 1947a). At this time it also became known that Oehlkers (1943) had succeeded in inducing translocations in flowering plants by a wide range of substances. Most effective of them was urethane, and this also has proved an effective mutagen for Drosophila in subsequent tests by Vogt (1948, 1950a). A third and fourth independent discovery of powerful mutagens...