Sedation with midazolam versus midazolam plus meperidine for routine colonoscopy: A prospective, randomized, controlled study

Abstract

Patient safety, outcomes, and satisfaction are similar in colonoscopy procedures performed under sedation protocols using either midazolam and meperidine or midazolam alone. Although endoscopists favor the use of both medications together, adding meperidine to midazolam before the colonoscopy does not seem to have additive beneficial effect for the patients.