Publication | Open Access
Ruthenium Catalyzed Reductive Coupling of Paraformaldehyde to Trifluoromethyl Allenes: CF<sub>3</sub>-Bearing All-Carbon Quaternary Centers
64
Citations
59
References
2013
Year
All-carbon Quaternary CentersInorganic ChemistryChemical EngineeringTrifluoromethyl AllenesReductive CouplingsEngineeringAlkene MetathesisCross-coupling ReactionOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryMolecular CatalysisSingle RegioisomersBiomolecular Engineering
Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF3-bearing all-carbon quaternary stereocenters.
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