Nocturnal Blood Glucose and IGFBP-1 Changes in Type 1 Diabetes: Differences in the Dawn Phenomenon between Insulin Regimens - Concepedia

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Nocturnal Blood Glucose and IGFBP-1 Changes in Type 1 Diabetes: Differences in the Dawn Phenomenon between Insulin Regimens

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2009

Year

Hideaki Yagasaki, Kunihisa Kobayashi, Koichiro Nagamine, Yuki Mitsui, M. Mochizuki, Kunihisa Kobayashi, H. Cho, K. Ohyama, Seiichiro Amemiya, Shoko Nakazawa

Experimental and Clinical Endocrinology & Diabetes

Abstract

The use of insulin regimens that provide sufficient insulin levels in the early morning can suppress the dawn phenomenon, leading to improved glycemic control. The increase in circulating IGFBP-1 in the morning, as a result of waning of insulin action, lowers free IGF-1 levels and may cause insulin resistance.