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Residual RNA Synthesis in Escherichia coli after Inhibition of Initiation of Transcription by Rifampicin
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1970
Year
EngineeringResidual Rna SynthesisMolecular BiologyEscherichia ColiAntimicrobial ChemotherapyProtein SynthesisDrug ResistanceBiosynthesisRna PolymeraseAntisense TherapyInhibitory ActivityAntimicrobial ResistanceRna ProcessingAntibacterial AgentAntimicrobial CompoundPolymerase MoleculesMolecular MicrobiologyPharmacologyRna ChainsSynthetic BiologyMicrobiologyMedicineDrug Discovery
Recent studies on the mechanism of action of rifampicin have shown that the drug inhibits the initiation of transcription by interacting with RNA polymerase without preventing the completion of RNA chains in the process of being synthesized (see Mosteller and Yanofsky, 1970, for a survey of the relevant literature). A technique has been developed to use the properties of this drug to study the distribution of polymerase molecules in bacterial cells and related problems concerning RNA synthesis.