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Studies of Nucleosides and Nucleotides. XXX. Syntheses of 8-Substitute Guanosine Derivatives
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1966
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Bioorganic ChemistryCases CleavageEngineeringMolecular BiologyOrganic Chemistry8-Substitute Guanosine DerivativesNucleoside LinkageHeterocycle ChemistryMedicinal ChemistryBiosynthesisNucleic Acid ChemistryPyrimidine RingDerivativesBiochemistryOligonucleotideNatural Product SynthesisBiomolecular EngineeringNatural SciencesNucleic Acid BiochemistryDerivative (Chemistry)Synthetic Chemistry
Starting from 8-bromoguanosine, 8-methylsulfonylguanosine, 8-dimthylaminoguanosine and 8-methoxyguanosine were synthesized. The reaction of 8-methylsulfonylguanosine with acid, alkali and t-butoxide were investigated. In the former two cases cleavage of nucleoside linkage was observed. In the latter case cleavage of pyrimidine ring probably occurred.