Application of NMR to Stereochemistry. (I). The Spatial Interaction Effect of the Hydroxyl Group to Methyl Resonance.(< ?? ?? >53)

Abstract

The spatial vicinity of hydroxyl and methyl groups caused a remarkable downward shift for the methyl signal and this relationship was acertained by the acetylation of the hydroxyl group, causing a characteristic upward shift. This relationship might be applied to various ring systems, e.g. steroids, diterpenes, etc., predicting the spatial relation between hydroxyl and methyl groups.