Catalytic sp³ C–H Oxidation of Peptides and Their Analogues by Radical Cation Salts: From Glycine Amides to Quinolines

Abstract

A catalytic α-sp(3) C-H oxidation of peptides and glycine amides was achieved under radical cation salt catalysis in the presence of O2, producing a series of substituted quinolines. The scope of this reaction shows good functional group tolerance and high efficiency of the oxidative functionalization.