Acute Generalized Exanthematous Pustulosis Caused by Faropenem: A Possible Pathogenetic Role for Interleukin-23

Abstract

© 2016 The Authors. doi: 10.2340/00015555-2225 Journal Compilation © 2016 Acta Dermato-Venereologica. ISSN 0001-5555 Faropenem is an oral beta-lactam antibiotic, which is structurally different from carbapenems and other available beta-lactams (1). Its administration is effective for upper respiratory tract infection (pharyngitis or tonsillitis), acute bronchitis, and other infectious disease (2). Although diarrhoea and vomiting occur occasionally as adverse effects of faropenem, cutaneous side-effects have not been reported in the English literature. Furthermore, beta-lactam antibiotics, such as meropenem (4), are a common cause of acute generalized exanthematous pustulosis (AGEP) (3); however, there has been no previous report of AGEP associated with administration of faropenem. We report here a first case of AGEP caused by faropenem.