Publication | Closed Access
Highly Enantioselective Synthesis of Cyclopropylamine Derivatives via Ru(II)-Pheox-Catalyzed Direct Asymmetric Cyclopropanation of Vinylcarbamates
84
Citations
32
References
2013
Year
Asymmetric CatalysisAsymmetric CyclopropanationExcellent DiastereoselectivityEngineeringHeterocyclicNatural SciencesDiversity-oriented SynthesisOrganic ChemistryCatalysisDirect Asymmetric CyclopropanationChemistryCyclopropylamine DerivativesHigh YieldPharmacologyStereoselective SynthesisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
The Ru(II)-Pheox-catalyzed asymmetric cyclopropanation of vinylcarbamates with diazoesters resulted in the corresponding cyclopropylamine derivatives in high yield and excellent diastereoselectivity (up to 96:4) and enantioselectivity (up to 99% ee).
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