Experimental Biology and Medicine · 1960 · 14 citations · 0 references
MedicineDermatologyPharmacotherapyHistologyImmunopathologyInflammationCorticosteroid PharmacologyCorticosteroid TherapyImmunopathology Of SkinInflammatory Skin DiseasesInflammatory Skin DisordersCorticosteroid ImmunosuppressionCorticosteroid Maintenance TherapyCorticosteroid RegimensCorticosteroid TherapeuticsDaily DosingDermatologic Corticosteroid TherapyImmunosuppressive Effects Of CorticosteroidsPrednisone Use
Dermal punch biopsies were obtained from 41 subjects prior to and following 2 weeks of daily medication with prednisone, methyl prednisilone or triamcinalone. The hexosamine-collagen ratio (H/C) was determined. In 32 subjects decrease in H/C values of 5% or greater were observed. The mean change in H/C in 35 patients following corticoid treatment was −12.9% ±1.5%.