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Immunochemical Studies of the Rh System: III. Quantitative Hemagglutination That Is Relatively Independent of Source of Rh Antigens and Antibodies
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1964
Year
HistocompatibilityImmunohematologyImmunocytochemical TechniqueImmunologyBlood CellPathologyImmunodominanceImmunotherapyRh Antibody MoleculesRh AntibodiesBioanalysisHematologyImmunochemistryAntibody EngineeringHealth SciencesAutoimmune DiseaseAllergyAutoimmunityAntibody ScreeningRh PleomorphismRh AntigensRh SystemQuantitative HemagglutinationMedicine
Genetically determined Rh pleomorphism arises not only from over 20 antigenic determinants but also from differences between and within phenotype classes related to the quantity of available antigen on the red cell surface. Additional heterogeneity is created by variability in the strength of binding of different populations of Rh antibody molecules. These problems have until now restricted the interpretation of quantitative data obtained from studies of either Rh hemagglutination (Silber, Gibbs, Jahn and Akeroyd, 1961, and Solomon, Gibbs and Bowdler, 1964) or the uptake of isotopically labeled Rh antibodies (Masouredis, 1960 and 1964). Although both antigens and antibodies will have to be purified and systematically characterized for an ultimate evaluation of Rh-anti-Rh reactions, preparations of isolated Rh antibodies have now permitted a partial solution of Rh-anti-Rh heterogeneity problems.