Effect of Spirolactone SC 8109 on Renal Function in Normal Human Subjects.

Abstract

Five normal, male, human subjects have been studied by the classical clearance technics during salt deprivation before and after therapy with the steroid-17-spirolactone, SC 8109. No change in the glomerular filtration rate or effective renal plasma flow could be demonstrated but a definite sodium diuresis and potassium retention occurred in response to the spirolactone. A small increase in free water clearance was seen in 4 of 5 subjects studied. These observations localize the effect of spirolactone to the renal tubule.