Effect of Adrenalectomy on Spontaneous and Induced Proteinuria in the Rat.

Abstract

Summary1. Bilateral adrenalectomy abolishes or greatly reduces the types of experimentally produced proteinuria studied in the saline maintained rat.2. The normal, spontaneous proteinuria of the male rat is significantly reduced by bilateral adrenalectomy.3. Cortisone administration to bilaterally adrenalectomized male rats increases their spontaneous proteinuria to normal control levels.4. Adrenal cortex extract, esoxycorticosterone acetate, and cortisone restore the ability of the salt-maintained, adrenalectomized rat to respond to renin injection with massive proteinuria.