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An Analytical Study and Anti-Inflammatory and Analgesic Effects of<i>Harpagophytum procumbens</i>and<i>Harpagophytum zeyheri</i>
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1997
Year
Bioorganic ChemistryAntiparasitic AgentAnalytical StudyHarpagophytum ProcumbensHarpagophytum ZeyheriInflammationPhytopharmacologyAnalgesic EffectsAllergyBiochemistryBioassay-guided IsolationPharmacologyAnti-inflammatoryNatural SciencesHerb-drug InteractionDrug Harpagophyti RadixPhytochemistryMedicineDrug DiscoveryDrug Analysis
The iridoids of Harpagophytum procumbens and Harpagophytum zeyheri were studied by CLHP. Harpagoside is the main iridoid for both drugs whereas 8-p-coumaroylharpagide is a representative iridoid of Harpagophytum zeyheri only. The ratio harpagoside/8-p-coumaroylharpagide can be used to distinguish chemically both species. For commercial dried aqueous extracts this ratio is intermediate because they are probably prepared from a mixture of H. procumbens and H. zeyheri drugs. The aqueous extracts of both drugs show similar analgesic and anti-inflammatory properties. Harpagophytum procumbens and Harpagophytum zeyheri should be accepted as sources for the drug Harpagophyti radix.