Aerobic Dehydrogenative Heck Reaction of Ferrocene with a Pd(OAc)₂/4,5-Diazafluoren-9-one Catalyst

Abstract

The aerobic dehydrogenative Heck alkenylation of ferrocene with alkenes, catalyzed by a Pd(OAc)2/4,5-diazafluoren-9-one system, is disclosed. Monoalkenylated ferrocenes were obtained in moderate yields and selectivities using various electron-poor alkenes. Oxygen at an atmospheric pressure was the sole oxidant. The reaction can be carried out at room temperature (several days) or at 70 °C (∼3 h).