Influence of Roflumilast on Airway Reactivity and Apoptosis in Ovalbumin-Sensitized Guinea Pigs

Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro

Armin Hatzelmann, Christian Schudt · Journal of Pharmacology and Experimental Therapeutics · 2001 · 398 citations

Medicine, Medicinal Chemistry, Pharmacology +10

In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor

Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 239 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Reduced eosinophil apoptosis in induced sputum correlates with asthma severity

C.J. Duncan, A. Lawrie, Morgan G. Blaylock et al. · European Respiratory Journal · 2003 · 113 citations · Full text

Medicine, Internal Medicine, Pathology +14

Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions

Emmerentia van Schalkwyk, Klara Strydom, Zelda Williams et al. · Journal of Allergy and Clinical Immunology · 2005 · 109 citations

Life Sciences, Pharmacology, Pharmacotherapy +14

Development status of second generation PDE4 inhibitors for asthma and COPD: the story so far.

M A Giembycz · PubMed · 2002 · 74 citations

Medicine, Medicinal Chemistry, Pharmacology +13