Bilateral Spreading Cerebral Hypoperfusion during Spontaneous Migraine Headache

TLDR

Although decreases in regional cerebral blood flow are known to occur in migraine, the precise pattern of these alterations has not been delineated. Serial xenon‑133 studies show that migraine attacks trigger a contiguous, spreading reduction in cerebral blood flow—spreading oligemia or hypoperfusion—observed consistently across multiple studies. Citation: Olesen et al.

Abstract

Although decreases in regional cerebral blood flow are known to occur in relation to migraine headache, the pattern of the alterations in blood flow has not been precisely delineated. Olesen et al. have described a series of patients who had migraine headaches during serial cerebral blood-flow measurement by the intracarotid xenon-133 technique.1 They observed a pattern of localized decreases in flow that appeared to spread contiguously along the cerebral cortex. These observations were confirmed in subsequent studies,2,3 and with very few exceptions1,4 the pattern of “spreading oligemia” or “spreading hypoperfusion”5 has been apparent only in patients who have . My. .