Metabolic Products of Fungi. XXV. Synthesis of Rubrofusarin and Its Derivatives.

Abstract

Rubrofusarin, a metabolic product of Fusarium culmorum Sacc. and its methyl ethers were synthesized by the Claisen condensation of 2-acetylnaphthalene derivatives (XIII, XV and XVIII), which were prepared starting from α-resorcylic acid. The structures of rubrofusarin monomethyl ether A and nor-rubrofusarin diacetate were established spectrometrically and synthetically.