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Abnormal Tryptophan Metabolites in Human Pregnancy and their Relation To Deranged Vitamin B6 Metabolism
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1954
Year
NutritionAbnormal Tryptophan MetabolitesGynecologyFetal HealthHigh-risk PregnancyHuman PregnancyG Dl-tryptophanToxicologyB6 Deficient RatsMaternal NutritionPublic HealthHuman MetabolismBiochemistryMaternal HealthGestational DiabetesMaternal-fetal MedicineMetabolomicsEndocrinologyPharmacologyPhysiologyForensic ToxicologyAbnormal SubstancesMetabolismMedicine
Following ingestion of 10 g Dl-tryptophan, normal subjects excrete kynurenine, kynurenic acid and occasionally Na-acetyl kynurenine. In pregnancy many additional metabolites, including 3-hydroxy-kynurenine, occur in the urine. The abnormal tryptophan metabolite excretion pattern in these women is strikingly similar to the one described in vit. B6 deficient rats. Administration of pyridoxine suppresses to a large degree the excretion of the abnormal substances.