Publication | Closed Access
Bioactivity of the Conjugation of Green-Emitting CdTe Quantum Dots with a Carborane Complex
11
Citations
0
References
2011
Year
Medicinal ChemistryGraphene Quantum DotPolymer-drug ConjugateCdte QdsFluorescence IntensityNatural SciencesMedicineColloidal NanocrystalsTumor TargetingAnti-cancer AgentChemistryChemical ProbeDerivative Cbac2PharmacologyBiomolecular EngineeringDrug DiscoveryCarborane Complex
In this report, we describe the effect of conjugating o-carborane-C(1)C(2)-dicarboxylic acid (o-C2B10H10-C2O4H2, denoted as Cbac2) to cadmium telluride quantum dots (CdTe QDs) capped with cysteamine on the photophysics and cytotoxicity of the QDs. Cbac2 quenches the fluorescence intensity and induces a red shift of the fluorescence emission peak. Meanwhile, studies with a real time cell electronic sensing (RT-CES) system and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay indicate that the combination of the carborane carboxylic acid derivative Cbac2 with relevant QDs can efficiently improve the inhibition efficiency for target cancer cells when compared with a single ligand or the CdTe QDs alone. This study raises the possibility for the labeling of the important pharmacophore with QDs and the design of new promising anticancer agents containing the carborane pharmacophores for cancer therapy.