Experimental Biology and Medicine · 1936 · 48 citations · 0 references
MedicineAnimal SciencesEndocrinologyLactationReproductive EndocrinologyReproductive PhysiologyEstrous CycleHormonal Regulation Of ReproductionOvarian FunctionOvarian PhysiologyPituitary Gland FunctionPituitary HormonesMammary Gland HistologyMammary Gland Hormonal RegulationOvarian AtrophyOvarian Hormone PhysiologyOvarian Hormone RegulationOvarian HormonesPituitary Control Of LactationPituitary Regulation Of Lactation
Daily administration of 4 mg. of synthetic progesterone to iiormally cyclic iemale rats causes immediate cessation of cycles, without vaginal mucification. There was ovarian atrophy, hypertrophy of the pituitary, and slight atrophy of the thymus. It has no effect n-hatsoever upon the condition of the mammary gland. Since cestrin is also without any direct effect upon the mammary gland (as shown in hypophysectomized animals) the effect of ovarian hormones on the mamma must be largely dependent upon the presence of pituitary secretions.