Analytical Performance of a Fiber Optic Probe Dissolution System

Abstract

issolution testing is a time-consuming and l a bo r -i nte n s i ve test proce d u re.The te c hnique re q u i res a sample of dissolution medium be re m oved from each of the te s t vessels at a specified time po i nt ( s ) . This sampling p roce d u re can be handled either manually or by means of an auto m ated sipper mechanism.Ea c h m e t h od has its own inhere nt errors assoc i ated with i t .The manual technique is subject to analyst va ria b i l i ty.Two of the most common errors assoc i ate d with the manual sampling technique are impro pe r sampling within the vessel and timing errors in s a m p l i n g.Ad d i t i o n a l l y,this is the most labo r -i nte ns i ve technique and is especially taxing fo r co nt ro l l e d -release fo rm u l at i o n s,which ofte n re q u i re 24-hour testing pe ri od s.Au to m at i c sampling techniques can save analyst labo r,but still re q u i re a good deal of mainte n a n ce and set-up t i m e.Al s o,a u to m ated sipping mechanisms are co m p l ex and co ntain many moving parts that ca n m a l f u n ct i o n ,resulting in sampling erro r s.Si p pe r mechanisms are prone to sample co nt a m i n at i o n , ca rryove r,b u b b l e s,d i l u t i o n ,f i l ter clog g i n g,a n d tubing leaks.