Palladium-Catalyzed Domino C–S Coupling/Carbonylation Reactions: An Efficient Synthesis of 2-Carbonylbenzo[<i>b</i>]thiophene Derivatives

Abstract

A facile and selective palladium-catalyzed domino procedure has been developed for the preparation of 2-carbonylbenzo[b]thiophene derivatives from 2-gem-dihalovinylthiophenols. This protocol involves intramolecular C-S coupling/intermolecular carbonylation cascade sequences and allows access to various highly functionalized benzo[b]thiophenes in moderate yields.