Biologic False-positive Reactions in Serologic Tests for Syphilis in Narcotic Addiction: Reduced Incidence during Methadone Maintenance Treatment

Abstract

Biologic false-positive (BFP) tests for syphilis was found in 23% of 69 New York heroin addicts. After 23 ± 7 months of methadone maintenance treatment, BFP decreased to 5.8%. No correlation between abnormalities in SGOT, alkaline phosphatase, albumin, total protein, and the presence or loss of BFP reactions was observed. Similarly, no correlation between serum IgM or IgG levels or latex-fixation titers and the presence or loss of BFP reactions was found. BFP is a nonspecific serologic abnormality seen in urban narcotic addicts, which is alleviated by methadone treatment, presumably as a result of reduced exposure to unknown antigens.