Viral DNA Sequences in Cells Transformed by Simian Virus 40, Adenovirus Type 2 and Adenovirus Type 5

Abstract

Until recently, the study of DNA tumor viruses has been an essentially syntactic subject. Those who have worked in the field commonly believe, for example, that there are interconnections between the expression of integrated viral genomes, the structure of cell surfaces and the growth properties of cells. They have been loathe to suppose that any matter could be adequately solved without yielding results which are heavy with implications for other problems. The dangers of this approach are clear enough: On occasion it has been difficult to distinguish situations where something is rationally perceived from those where it is intuitively sensed. On the whole, however, the anastomosis of various features has worked out well: it has resulted in a groundplan on which the apparently diverse elevations of a fast-growing field can quickly be sited with respect to one another.