Synthesis of Deoxyribonucleic Acid in the Liver of Hypophysectomized Rats After Partial Hepatectomy.

Abstract

DNA synthesis in regenerating liver following partial hepatectomy of normal and hypophysectomized rats was measured following administration of thymidine-6-T(n). Such DNA synthesis in the hypophysectomized animals exhibits a delayed start and a prolonged period before its peak is reached, as compared with intact animals. However, there is a prolongation of maximal incorporation of DNA precursor, and a slower decline of DNA synthesis in hypophysectomized rats. The promotion of enzyme activity involved in DNA synthesis may be linked to the pituitary effects upon messenger RNA formation.