Lupus Erythematosus Treated with a Combination of Quinacrine, Hydroxychloroquine and Chloroquine*

Abstract

THIS study was undertaken as a clinical evaluation of the treatment of lupus erythematosus with a tablet composed of quinacrine, 25 mg., hydroxychloroquine, 50 mg., and chloroquine, 65 mg.¶ Certain antimalarial drugs have been shown to be more effective than any therapy previously available in treatment of chronic discoid lupus erythematosus. The literature on the use of quinacrine,1 , 2 hydroxychloroquine3 , 4 and chloroquine5 is already extensive. We have studied therapeutic and maintenance doses, relapses and side effects of this combination.The action of and the rationale for the use of these antimalarial drugs in lupus erythematosus have been the subject of some . . .