Catalytic Radical Cation Salt Induced C_sp³–H Functionalization of Glycine Derivatives: Synthesis of Substituted Quinolines

Abstract

A domino C(sp(3))-H functionalization of glycine derivatives was achieved under catalytic radical cation salt induced conditions, producing a series of quinolines. The proposed mechanism shows that a peroxyl radical cation, which is generated by the coupling between O(2) and TBPA(+•), might be involved to initiate the catalytic oxidation.