Synergistic Action of Pneumococci and Leukocytes in Lowering Cerebrospinal Fluid Glucose.

Abstract

Cerebrospinal fluid containing leukocytes was inoculated with a known quantity of pneumococci and incubated at 37°C. Under these conditions the fall in glucose was greater than when bacteria were incubated with cell-free CSF or when leukocytes were incubated in absence of bacteria. The data indicate that cells and bacteria act synergistically in producing the decrease in CSF sugar in bacterial meningitis.