Modulation of the number and functions of endothelial progenitor cells by interleukin 1β in the peripheral blood of pigs

Abstract

These results demonstrate that there is a negative cause-effect relationship between IL-1β and EPCs. Thus, IL-1β inhibits EPC proliferation, migration, adhesion, and tube formation by a mechanism, which involves p38 MAPK signaling in regulating the number and functions of EPCs in vitro.