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A Possible Experimental Approach to the Association of Hereditary 1-Antitrypsin Deficiency and Pulmonary Emphysema.
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References
1966
Year
AsthmaInflammatory Lung DiseaseAdvanced Lung DiseaseLung InflammationImmunologyPulmonary EmphysemaPathologyPulmonary Alveolar ProteinosisOxidative StressPossible Experimental ApproachPulmonary PharmacologySerum α1-AntitrypsinHuman SerumProteomicsAllergyPulmonary FibrosisPulmonary MedicineTranslational ProteomicsPulmonary DiseasePulmonary Vascular DiseaseAi-antitrypsin DeficiencyHereditary 1-Antitrypsin DeficiencyMedicine
SummaryProteolytic enzymes from various cellular sources were tested against pro-teinase inhibitors of human serum. Serum α1-antitrypsin was shown to inhibit the proteolytic enzymes of human leucocytes. This finding was interpreted in relation to the association between ai-antitrypsin deficiency and pulmonary emphysema.