Interactions Between Giant Unilamellar Vesicles and Charged Core−Shell Magnetic Nanoparticles

Abstract

This work combined two tools, giant unilamellar vesicles (GUVs) and core−shell magnetic nanoparticles (CSMNs), to develop a simplified model for studying interactions between the cell membrane and nanoparticles. We focused on charged functionalized CSMNs that can be either cationic or anionic. Using optical, electron, and confocal microscopy, we found that giant vesicle−nanoparticle interactions did not result from a simple electrostatic phenomenon because cationic CSMNs tended to bind to positively charged bilayers, whereas anionic CSMNs remained inert.