Laboratory Medicine · 1989 · 22 citations · 0 references
MedicineHematologyPharmacologyHemostasisPharmaceutical ToxicologyRodent MedicineAnticoagulant TherapyAnticoagulant ToxicityAnticoagulation TherapyCoagulation AbnormalitiesHematologic ToxicityRodenticide PoisoningAnticoagulant PharmacologyAnticoagulant Rodenticide ToxicityVitamin K Antagonist OverdoseVitamin K Deficiency Secondary To RodenticidesWarfarin Toxicity
Inhibition of normal clotting is a result of rodenticides being applied to rodents in an effort to exterminate them. However, the rodenticides are also readily available for human consumption. We report a fatal ingestion of brodifacoum, a long-acting warfarin-like anticoagulant found in Havoc rodenticide. To our knowledge, this is the first such fatality reported. This case illustrates the typical clinical presentation, therapeutic alternatives, and responses to vitamin K-antagonizing anticoagulant overdoses.