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One-Pot Regioselective Synthesis of Imidazole and 2,3-Dihydroquinazolinone Derivatives - An Easy Access to ‘Nature-Like Molecules'; Part XIII in the Series: ‘Studies on Novel Synthetic Methodologies'
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2013
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Diversity Oriented SynthesisNatural Product SynthesisEngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistryNature-like MoleculesOne-pot Regioselective SynthesisChemistryHeterocycle ChemistryPractical Regioselective SynthesisPharmacologyRelevant Natural-product-like ScaffoldsAcetic AcidSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNovel Synthetic Methodologies
A mild and highly practical regioselective synthesis of imidazole and 2,3-dihydroquinazolinone derivatives from 5-alkyl-4-hydroxyisophthalaldehydes with suitable substrates in acetic acid is reported. Further exploration of the molecular diversity of 2,3-dihydroquinazolinone is demonstrated by the synthesis of diverse pharmacologically relevant natural-product-like scaffolds.